Ross, J.L., Z. Chen, C.J. Herting, F. Szulzewsky, M.P. Vallcorba, L. Monterroza, J. Switchenko, P.J. Cimino, A. Mackay, C. Jones, R.D. Read, T. MacDonald, M. Schniederjan, O.J. Becher, D. Hambardzumyan. 2020. PDGFB is a Potent Inflammatory Driver in Paediatric High-Grade Glioma. Brain. Dec 10;awaa382 doi: 10.1093/brain/awaa382.

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Vigneswaran, K., N.B. Boyd, S. Lallani, S.-Y. Oh, A. Boucher, S. Neill, J.J. Olson, R.D. Read. 2020. YAP/TAZ transcription factors create therapeutic vulnerability to verteporfin in EGFR mutant glioblastoma. Clinical Cancer Research. Nov 10;clincanres.0018.2020.doi: 10.1158/1078-0432.CCR-20-0018.

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Chen, Z., C.J. Herting, J.L. Ross, B. Gabanic, M.P. Vallcorba, F. Szulzewsky, M.L. Wojciechowwicz, P.J. Cimino, R. Ezhilarasan, E.P. Sulman, M. Ying, A. Ma’ayan, R.D. Read, D. Hambardzumyan. 2020. Genetic driver mutations introduced in identical cell-of-origin in murine glioblastoma reveal distinct immune landscapes but similar response to checkpoint blockade. Glia. Oct;68(10):2148-2166. doi: 10.1002/glia.238.

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Chen, A. and R.D. Read. 2019. Drosophila melanogaster as a Model System for Human Glioblastomas. Book chapter for “Drosophila Models in Cancer.” Springer Nature., edited by W.M. Deng. 

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Robinson, H., S. Lallani, H. Farooq, M.D. Taylor, R.D. Read, A.M. Kenney. 2019. Upregulation of the chromatin remodeler HELLS is mediated by YAP1 in Sonic Hedgehog Medulloblastoma. Science Reports. 2019 Sep 20;9(1):13611. doi: 10.1038/s41598-019-50088-1.

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Chen, A., J. Wardwell-Ozgo, N. Shah, D. Wright, C. Appin, K. Vigneswaran, D. Brat, H. Kornblum, R.D. Read. 2018. Drak/Stk17A drives neoplastic glial proliferation through modulation of MRLC signaling. Cancer Research. doi.org/10.1158/0008-5472.CAN-18-0482.

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Read, R.D. 2018. The Pvr receptor tyrosine kinase signaling promotes post-embryonic morphogenesis and survival of glia and neural progenitor cells in Drosophila. Development. doi: 10.1242/dev.164285.

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Mukherjee, S. C. Tucker-Burden, E. Kaissi, A. Newsam, M. Chau, C. Zhang, B. Diwedi, M. Rupji, S. Seby, J. Kowalski, J. Kong, R.D. Read, D. J. Brat. 2018. CDK5 inhibition resolves PKA/cAMP-independent CREB1 phosphorylation in glioma stem cells. Cell Reports 23(6):1651-1664. 

doi: 10.1016/j.celrep.2018.04.016.

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Mukherjee, S. C. Tucker-Burden, C. Zhang, K. Moberg, R. Read, C. Hadjipanayis, D.J. Brat. 2016. Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport. Cancer Research 76(8):2443-52. 

doi: 10.1158/0008-5472.CAN-15-2299

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Read, R.D., T.S. Fenton, G. Gomez, J. Wykosky, S.R. Vandenberg, I. Babic, H. Yang, A. Iwanami, P.S. Mischel, W.K. Cavenee, F.B. Furnari, J.B. Thomas.  2013. A kinome-wide RNAi screen in Drosophila glia reveals that the RIO kinases mediate cell proliferation and survival through TORC2-Akt signaling in glioblastoma. PLoS Genetics 9(2):e1003253.  

doi: 10.1371/journal.pgen.1003253.

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Read, R.D. 2011. Drosophila melanogaster as a model system for human brain cancers. Glia. 2011 Sep; 59(9): 1364–1376. PMC3221733.

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Read, R.D., W.K. Cavenee, F.B. Furnari, J.B. Thomas. 2009. A Drosophila model for EGFR-Ras and PI3K dependent human glioma. PLoS Genetics 5(2):e1000374. doi: 10.1371/journal.pgen.1000374.

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Vidal, M., S. Warner, R.D. Read, R.L. Cagan. 2007. Differing Src signaling levels have distinct outcomes in Drosophila.  Cancer Research 67:10278-10285. doi: 10.1158/0008-5472.CAN-07-1376.

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Read, R.D., P.J. Goodfellow, E.R. Mardis, N. Novak, J.R. Armstrong, R.L. Cagan. 2005. A Drosophila model of Multiple Endocrine Neoplasia type 2.  Genetics 171:1057-1081. doi: 10.1534/genetics.104.038018.

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Read, R. D., E.A. Bach, R. L. Cagan.  2004.  Drosophila C-terminal Src kinase negatively regulates organ growth and cell proliferation through inhibition of the Src, Jun N-terminal kinase, and STAT pathways. Molecular and Cellular Biology 24:6676-6689. doi: 10.1128/MCB.24.15.6676-6689.2004.

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Miller, D T., R. Read, J. Rusconi, R.L. Cagan. 2000. The Drosophila primo locus encodes two low-molecular-weight tyrosine phosphatases. Gene 243: 1-9.

doi.org/10.1016/S0378-1119(99)00553-3.

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Read, R.D., J.M. Lionberger, T.E. Smithgall. 1997. Oligomerization of the Fes tyrosine kinase. Journal of Biological Chemistry. 272:18498 18503. 

doi:10.1074/jbc.272.29.18498

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Rogers, J.A., R.D. Read, J. Li, K.L. Peters, T.E. Smithgall. 1996. Autophosphorylation of the Fes tyrosine kinase: evidence for an intermolecular mechanism involving two kinase domain residues. Journal of Biological Chemistry 271: 17519-17525. doi: 10.1074/jbc.271.29.17519.

 

 

Manuscripts Submitted/In Revision

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Chen, A.S., J. Marquez, N.H. Boyd, S.-Y. Oh, R. Gulbronson, J.A.G. Hamilton, E.R. Legan, R.D. Read.** RIOK2 drives glioblastoma cell growth and proliferation by modulating MYC through the RNA binding protein IMP3. in revision for eLife, 12/20 released on Bioarchives: doi: https://doi.org/10.1101/ 2020.12.07.413385.